The lamellar liquid crystalline gel (Lamellar Gel) which has the same structure as stratum corneum lipids was developed with synthesized lipids. We report its mechanism of constitution and skin care properties.
Lamellar Gel was formed by controlling the molecular behavior in two ways. One was making an optimal condition to increase the strength of hydrogen bond in hydrophibic region. The other was an addition of amphiphatic-molecules which have high affinity to incorporate a large amount of water within lamellar membrane.
Skin care properties of Lamellar Gel were compared to those of ordinary emulsion regarding in permeability, skin hydration and skin occlusion. Lamellar Gell was found to have higher affinity for skin, and hence higher permeability of the main components into the stratum corneum. Lamellar Gel supplied more water continuously because it contained more bound water. The skin is occluded by being covered with oil. Therefore, W/O emulsion and Lamellar Gel had high occlusion. Water content of stratum was enhanced by increasing both of these two parameters. It was clear that Lamellar Gel was the most suitable type of skin hydration.
Transepidermal water loss increases under dry environment. This condition influences the parts around the eyes, where the skin is very thin, and wrinkles are easily formed. Treating with Lameller Gel recovered these wrinkles promptly and hydrated stratum corneum for a long time.
View full abstract