The health, clinic, and education information evaluation institute (HCEI) develop databases derived from nerborn to school age health check-ups under the contract with local governments in Japan, and epidemiological analyses are provided to both individuals and local governments. The anonymized database is maintained for the secondary epidemiology research by researchers. On the other hand, HCEI aldo develops anonymized clinical database (RWD-DB) derived from electric medical record of hosipitals in Japan. Eplidemiological analyses utilizing RWD-DB is provided to hosipitals for the purpose of improvement of clinical outcomes and safety. These initiatives are important not only for the research basis but also for the health policy and helath-related industry.